Extra-high dose hepatitis B vaccination for peritoneal dialysis patients: a randomised controlled trial.
نویسندگان
چکیده
1. The response rate to recombinant hepatitis B vaccine was suboptimal (70.1%) in the peritoneal dialysis population. 2. We investigated whether a three-dose regimen of extrahigh dose (80 μg) of Engerix-B would achieve a higher rate of primary seroconversion and more persistent seroprotection in peritoneal dialysis patients, compared with the conventional 40-μg dose. 3. The rates of seroconversion (hepatitis B surface antibody level of ≥10 IU/L 3 months after treatment) were not significantly different between the two regimens. 4. The normalised protein nitrogen appearance was the only predictor for the development of primary seroconversion and persistent seroprotection. 5. Although the extra-high-dose regimen had no significant clinical benefit, improved protein intake may improve the immune response to hepatitis B vaccine in peritoneal dialysis patients.
منابع مشابه
Serum albumin level as an indicator of response to Hepatitis B vaccination in dialysis patients: A systematic review and meta-analysis
Background: Hepatitis B (HB) vaccination is a recommended procedure in all dialysis patients, but its efficacy has not been perfect. In the current study, we aimed to conduct a comprehensive review of the literature to find and pool data of the randomized trials evaluating the impact of serum albumin levels on the immunogenicity of HB vaccination in dialysis patients. Methods: Literature searc...
متن کاملبررسی ارتباط میزان روی سرم و پاسخ ایمنی هومورال به واکسیناسیون هپاتیت B در بیماران دیالیزی
Introduction: Zinc deficiency causes abnormalities in immune response. In chronic hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) patients, impaired immune responses to vaccination have been reported. Therefore, we performed a study to determine the correlation between serum zinc levels and immune response to hepatitis B vaccination in patients on dialysis. Methods: A cr...
متن کاملAntibody response following Hepatitis B vaccination in peritoneal dialysis patients: does normalized urea clearance matter?
OBJECTIVES Data on the factors that contribute to the antibody response to hepatitis B virus vaccination in peritoneal dialysis patients are scarce. The current study was conducted on a group of peritoneal dialysis patients to learn how the response to hepatitis B virus vaccination varies according to the patient's clearance of urea normalized to total body water (Kt/V). METHODS A convenience...
متن کاملAssociation of response to hepatitis B vaccination and survival in dialysis patients
BACKGROUND The status of immunocompromised patients is well recognized in end stage renal disease (ESRD). As described recently, this acquired immune dysfunction in the uremic milieu may be one of the main pathogenic factors for mortality in ESRD. The aim of this study was to determine the relationship between the immune response following a hepatitis B vaccination (HBV vaccination) and the sur...
متن کاملVaccination against hepatitis B infection in patients with end stage renal disease.
BACKGROUND Experience of hepatitis B vaccination in a contemporary renal replacement programme is reported. METHODS A total of 406 patients were involved: 214 on haemodialysis, 97 on continuous ambulatory peritoneal dialysis, 67 predialysis (serum creatinine >400 micromol/l), and 28 with a failing transplant. Primary vaccination comprised recombinant hepatitis B vaccine (Engerix B) 40 microg ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Hong Kong medical journal = Xianggang yi xue za zhi
دوره 18 Suppl 6 شماره
صفحات -
تاریخ انتشار 2012